Explore the top 10 startups in Philadelphia driving innovations across industries. This article showcases companies impacting healthcare, real estate, pest control, and carbon management. From RFID-enabled freezer racks to voice-activated security solutions and automated pest inspections, these startups highlight Philadelphia’s dynamic ecosystem. Explore how these ventures are reshaping industries with advanced technologies and enabling sustainable growth.
10 Startups in Philadelphia to Watch in 2025
- Gnosko Bio – RFID-tagged Freezer Racks
- Toetal Solutions – Hammertoe System
- Cecilian Partners – Real Estate Development Management
- AeroPest – Drones and AI-powered Automated Pest Inspections
- Praktikant – Document Management Platform
- Carbon Reform – Direct Air Capture
- Standard Carbon – Carbon Emissions Recycling
- Poolside Tech – Pool Automation
- Emergence Technology Group – Voice-activated Security Solution
- VESTECK – Catheter Delivery System and Suture
Meet 10 Startups in Philadelphia to Watch in 2025
1. Gnosko Bio
- Founding Year: 2020
- Location: Wayne, Pennsylvania, USA
- Use For: Lab Inventory Management
Gnosko Bio offers ChillView Freezer Rack for storage solutions in ultra-low temperature freezers. These freezer racks are made of polymer which improves visibility by eliminating the need to remove the racks and boxes to find an item, specimen, or sample.
The racks also don’t need any protective gloves and are cost efficient due to efficiency in item retrieval as freezer doors need to be opened for lesser time saving on energy consumption.
Moreover, the startup integrates RFID technology on every product for easier tracking. This enables tracking of product activity monitoring usage, setting reorder thresholds, and autonomously placing orders.
Ginkgo Bioworks also expanded its partnership with Novo Nordisk to improve diabetes and obesity medication manufacturing using a flexible R&D model.
2. Toetal Solutions
- Founding Year: 2021
- Location: Malvern, Pennsylvania, USA
- Use For: Implants for Hammertoe Deformities
Toetal Solutions advances surgeries for hammertoe deformities with its ZipToe hammertoe system that enables foot and ankle surgeons to address rigid hammertoe deformities.
This solution incorporates a user-friendly design meeting the core tenets of proper bone fusion for precision and stability. It is simple to implant, provides active compression, and eliminates rotation for better clinical outcomes.
Additionally, it benefits ambulatory surgery centers (ASC) as it offers deployable nitinol implants that come sterile-packed with all necessary disposable instrumentation to perform the procedure in any surgical setting.
3. Cecilian Partners
- Founding Year: 2019
- Location: New Hope, Pennsylvania, USA
- Use For: Automating Manual Real Estate Management
Cecilian Partners offers Residential OS to digitize the entire real estate development process. Residential OS offers multiple tools such as Lot Vault, Xplorer, The XO, Brightdoor, and Customer Blueprint.
Lot Vault is an enterprise software-as-a-service (SaaS) platform that digitizes, streamlines, and clarifies everything from lot takedowns and approvals to document management and reporting.
Xplorer maps offers 3D maps of the community with interactive technology. The XO centralizes data, automates processes, and streamlines communication, making it easier to sell homes and develop communities.
BrightDoor provides real-estate-specific customer relationship management (CRM), digital registration, and storytelling solutions that ease communication with home buys.
Further, Customer Blueprint is an all-in-one platform that includes an app for resident engagement to simplify community management.
Cecilian Partners also acquired BrightDoor to improve customer interaction management and its PropTech services.
4. AeroPest
- Founding Year: 2019
- Location: Philadelphia, Pennsylvania, USA
- Use For: Automated Pest Inspections
AeroPest offers AEROPEST.AI for automated pest inspections using drones and AI. This solution merges AI, object detection, and autonomous drones to provide inspection details on an app.
The user connects to the drone, taps upload and the AI analyzes the captured drone data and produces a report of present pests.
This solution offers faster inspections of buildings and infested areas efficiently, saving time. It further protects the workers by keeping them off ladders, lifts, and rooftops.
5. Praktikant
- Founding Year: 2023
- Location: King of Prussia, Pennsylvania, USA
- Use For: Enhancing Client Engagement
Praktikant provides Prak, an intelligent agent that works in the background by securely integrating and operating an organization’s diverse software stack.
This improves client engagement and enables simpler management of documents by automatically generating client performance reports and capturing relevant client communications.
It also enables naming and saving documents to cloud storage from emails and web sources and compiling files, policies, and communications for each client.
Prak operates in real-time within the email and also handles data entries in CRM, performance reporting, and task management platforms.
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6. Carbon Reform
- Founding Year: 2020
- Location: Philadelphia, Pennsylvania, USA
- Use For: Reducing Building Emissions
Carbon Reform offers solutions to provide a healthier indoor environment while reducing building emissions and cutting utility costs. It offers Carbon Capsules and Carbon Canisters for improving the building’s air quality.
Carbon Capsule cleans indoor air for better indoor air quality by scrubbing air of CO₂, volatile organic compounds (VOCs), pathogens, and particulates with advanced sorbent and filters.
It permanently stores captured CO₂ in a carbon-negative limestone cartridge which is later collected for recycled materials.
Further, Carbon Canister is a freestanding plug-and-play unit that boosts productivity with healthy indoor air.
It also offers a plug-and-play IO IAQ Sensor that provides insights into 7 critical air quality parameters including carbon dioxide (CO₂), the total volatile organic compound (TVOC), and particulate matter (PM).
7. Standard Carbon
- Founding Year: 2020
- Location: Wilmington, Delaware, USA
- Use For: Converting Surplus Electricity to Carbon-neutral Natural Gas
Standard Carbon’s technology uses renewable electricity to convert CO2 into natural gas. It offers CARBON BRIDGE, a clean energy solution that simultaneously generates two revenue streams.
The technology works as a seasonal energy storage technology where market price volatility is leveraged to produce natural gas. It connects renewables to capacity markets and also acts as a powerful grid stabilizer that accelerates the renewable transition.
Moreover, it acts as a decarbonization solution where CO2 is converted to carbon-neutral pipeline-grade natural gas (e-RNG). It is a beneficial alternative to permanent sequestration.
8. Poolside Tech
- Founding Year: 2019
- Location: New Hope, Pennsylvania, USA
- Use For: Smart Pool Automation Technology
Poolside Tech offers The Attendant to improve all aspects of the pool ownership experience. This cloud-based automation system continually monitors equipment, water quality, and temperature to determine the most energy-efficient way to have a poolside oasis ready when needed.
The Attendant’s technology checks for the desired temperature of the pool, the weather forecast, and energy rates to determine the cheapest way to get the right temperature.
It keeps a check on the water quality by keeping a check on mundane chores like managing sanitizer, filtration, pH balance, and alkalinity by dispensing chemicals to address any imbalances.
The technology also reacts to algae or extra heavy pool use by automatically boosting sanitizer and filtration run times.
Further, Poolside Tech secured a substantial USD 500 million in a Series B funding round led by Bain Capital Ventures.
9. Emergence Technology Group
- Founding Year: 2021
- Location: Philadelphia, Pennsylvania, USA
- Use For: Personal and Public Safety
Emergence Technology Group improves personal and public safety with MyVoice. It is a voice-activated security solution with biometric speech authentication.
This software-as-a-service (SaaS) model eliminates the need for panic buttons or keypads. This solution connects to emergency services without needing any confirmation in case of home invasions, medical emergencies, stalking, domestic violence, abduction, and more.
It does not store any information on the cloud and is easily accessible with a wake word along with the trigger to initiate the process.
The solution also offers features like being discreet while calling for assistance, location-specific, sharing route notifications and critical information, and convenient with a plug-and-play setup.
10. VESTECK
- Founding Year: 2019
- Location: West Chester, Pennsylvania, USA
- Use For: Endovascular Aneurysm Repair
VESTECK offers Suture-Tight delivery system and suture to advance endovascular aneurysm repair procedures. This solution delivers preloaded sutures that secure endovascular aortic repair grafts (EVAR/TEVAR) to the aorta during initial implant or repair procedures.
In addition, the delivery system enables physicians to implant up to 4 sutures with a single insertion. Suture-Tight is further designed from nitinol to behave like a surgeon’s suture and each endosuture works as a pair of surgical sutures.
Moreover, Vesteck closed a USD 4.3 million Series A financing round, led by New World Angels with a USD 1.1 million investment.
Discover All Emerging Startups in Philadelphia
The 1540+ startups in Philadelphia showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach.
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