Boston startups are at the forefront of innovation across multiple industries, offering cutting-edge solutions that address critical business and societal needs. Solutions range from marketing automation platforms to molecular diagnostics, representing a diverse range of sectors, including drug discovery, AI governance, cybersecurity, and sustainable energy solutions.
This report provides a glimpse into the vibrant and dynamic world of Boston startups, showcasing how they drive technological advancements, improve healthcare outcomes, and promote sustainability.
10 Emerging Tech Companies in Boston (2025)
- Maestra – Marketing Automation Platform
- 3EO Health – Molecular Quality Enhancement
- Hosta AI – Automated Property Assessment
- OnRamp – Collaborative Onboarding Management
- Mariana Oncology – Radiopharmaceuticals
- KineoLabs – Retinal Imaging
- Monitaur – AI governance software
- Cala Systems – Intelligent Heat Pump
- Zifino – External Attack Surface Management
- Rubik Therapeutics – Solid Tumor Therapy
Global Startup Heat Map highlights 10 Boston Startups to Watch
Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 4 760 120+ startups & scaleups globally, we identified 3204 Boston startups. The Global Startup Heat Map below highlights the 10 Boston startups you should watch in 2025.
As the world’s largest resource for data on emerging companies, the SaaS platform enables you to identify relevant technologies and industry trends quickly & exhaustively.
The 10 hand-picked startups highlighted in this report are chosen from all over Boston and develop solutions for radiopharmaceuticals, drug discovery, automated copy testing, and more.
Discover 10 Top Tech Companies in Boston (2025)
1. Maestra
- Founding Year: 2022
- Industry: eCommerce
- Solution: Marketing Automation Platform
Maestra offers a marketing automation platform for e-commerce, online retail, and direct-to-consumer (DTC) brands. It streamlines customer journey management and campaign conversions through a unified platform that integrates loyalty engines, website personalization, media, and omnichannel communications such as email, SMS, and push notifications.
Maestra’s commerce-specific data model delivers enterprise-grade capabilities to mid-sized brands that enable them to achieve significant improvements in journey conversion rates. This increases revenue while reducing costs and time spent on routine marketing tasks.
2. 3EO Health
- Founding Year: 2021
- Industry: Healthcare
- Solution: Molecular Quality Diagnosis
3EO Health develops a molecular diagnostics platform making high-quality molecular testing accessible and affordable at the point of care. The startup’s proprietary 3TR amplification system provides PCR-level sensitivity and specificity, which enables early and accurate detection of infectious diseases with minimal sample preparation.
The platform simplifies workflows, saving time and reducing operational costs eliminating complex lab procedures. 3EO Health offers a compact, preparation-free diagnostic device that performs at a molecular standard while being priced competitively at antigen levels. This empowers healthcare providers by making high-quality diagnostics affordable and accessible which improves patient care in clinical settings and beyond.
3. Hosta AI
- Founding Year: 2020
- Industry: PropTech
- Solution: Property Assessment Software
Hosta AI develops automated property assessment software that transforms simple photos into detailed structural and spatial representations. The startup’s artificial intelligence technology processes images taken with any camera or mobile device, which eliminates the need for specialized equipment or applications.
Hosta AI’s platform generates comprehensive assessments, including measurements, floor plans, CAD models, and itemized bills of materials, all without requiring on-site visits. This approach streamlines various assessment types, from spatial and damage evaluations to risk assessments, which offer instant insights into property conditions.
The startup’s patented AI spatial and material analysis, Hosta AI, accelerates the assessment process for residential and commercial properties, enabling remote inspections with just a few photographs. The technology’s versatility allows for seamless integration into existing workflows through configurable APIs, making it particularly valuable for contractors, insurers, and property managers.
4. OnRamp
- Founding Year: 2020
- Industry: Retail
- Solution: Collaborative Onboarding Management
OnRamp offers a collaborative onboarding management platform that streamlines and automates customer onboarding processes for B2B companies. The platform provides a comprehensive solution that includes both an internal project management system and a no-code customer portal.
This combination allows onboarding and implementation managers to simplify complex, high-touch onboarding processes. This reduces manual tasks for teams and makes it easier for customers to complete their onboarding steps.
The platform also identifies and resolves workflow bottlenecks quickly which enables smoother project progression while ensuring customer satisfaction.
5. Mariana Oncology
- Founding Year: 2021
- Industry: Healthcare
- Solution: Radiopharmaceuticals
Mariana Oncology develops radiopharmaceutical treatments for solid tumors. The startup combines ligand discovery, radiochemistry, radiobiology, and oncology research to create a pipeline of targeted radiopharmaceuticals. These therapeutics deliver radiation precisely to tumor sites using a combination of radioisotopes and targeting ligands that minimize damage to healthy tissues.
The platform allows for the development of therapeutic and diagnostic radiopharmaceuticals, which facilitate personalized treatment approaches for each patient’s needs. The radioconjugation platform provides safe, effective, and highly targeted therapies that assist patients with challenging solid tumors.
In 2023, Mariana Oncology received a series B funding of USD 175 million from Deep Track Capital, Forbion along with a few more leading biotechnology investors.
Interested in exploring all 3200+ Boston-based startups & scaleups?
6. Copybara
- Founding Year: 2021
- Industry: Media
- Solution: Automated Copy Testing
Copybara provides AI-powered copy optimization for marketers and growth teams. The startup’s technology automates the process of copy testing for ads and landing pages, generating and analyzing numerous variations simultaneously. It operates through an always-on learning loop that reallocates traffic hourly to maximize conversion lift from each experiment.
Copybara integrates with existing marketing channels and allows users to set brand and legal guidelines during onboarding. The system then generates copy variations based on AI analysis of the user’s landing pages.
As visitors interact with the pages, Copybara continuously learns and improves the copy. This approach enables marketers to run hundreds of ad and landing page copy tests in days, reducing the time and effort typically required for large-scale copy testing. Copybara’s solution addresses the challenge of manual copy testing, which often gets deprioritized due to resource constraints.
7. Monitaur
- Founding Year: 2019
- Industry: Cross Industry
- Solution: AI Governance Software
Monitaur is an AI governance software that enables companies to build, manage, and automate responsible AI governance across its modeling systems. As businesses increasingly leverage AI and big data, Monitaur helps mitigate operational, regulatory, financial, and legal risks through a comprehensive system that spans from policy creation to proof of compliance.
The platform offers a centralized system of record that fosters collaboration among cross-functional teams, ensuring that AI models are fair, transparent, robust, safe, and compliant.
8. Cala Systems
- Founding Year: 2020
- Industry: Heating
- Solution: Intelligent Heat Pump
Cala Systems develops an intelligent heat pump water heater that optimizes heating based on the unique schedule and priorities of a household. Cala’s intelligent controls automatically adjust to the preferences of individual households without the need for manual programming.
The system learns hot water usage patterns and adjusts its heating to ensure maximum efficiency and comfort. Cala features the ability to sync with a home’s solar system to reduce the carbon footprint and lower energy costs. It also preheats water before potential power outages to ensure the availability of hot water around the clock.
9. Zifino
- Founding Year: 2023
- Industry: Cybersecuirty
- Solution: External Attack Surface Management
Zifino is a self-service cybersecurity platform developed by MIT engineers, offering advanced external attack surface management (EASM) to protect digital assets. The platform provides automated vulnerability scanning for websites and publicly accessible digital assets, detecting exposed ports, hidden entry points, and unsecured directories that could be exploited by cyber attackers.
Zifino’s features include SSL assessment and subdomain scanning, ensuring comprehensive protection against vulnerabilities. Designed for organizations of all sizes, Zifino combines cutting-edge technology with a user-friendly interface to deliver robust cybersecurity at a low cost.
10. GreenFeet
- Founding Year: 2020
- Industry: Cross Industry
- Solution: Carbon Footprint Tracker
GreenFeet offers a carbon footprint tracking platform for businesses of all sizes. The startup’s technology streamlines measuring, analyzing, and reducing corporate emissions across scopes 1, 2, and 3 of the GHG protocol. The platform allows users to upload or plug-in data from various emission sources, which is then securely stored in a cloud-based carbon ledger.
GreenFeet’s intuitive dashboard allows organizations to drill down, segment, and analyze their emissions data, enabling them to identify areas for improvement and track the effectiveness of sustainability initiatives.
The platform provides rapid implementation. By offering real-time visibility, easy-to-generate reports, and cost-effective solutions, GreenFeet empowers organizations to take control of their carbon footprint.
Discover All Emerging Tech Companies in Boston
The 10 tech companies in Boston showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach.
Download our free Industry Innovation Reports for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025!
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